ICD↔CPT crosswalk
CPT J2791: ICD-10 codes that support medical necessity
These ICD-10-CM diagnoses support medical necessity for CPT J2791 under Medicare coverage policies (LCDs, NCDs, and Billing & Coding articles). Billing CPT J2791 with a diagnosis that isn't covered typically denies as CARC 50 — not medically necessary.
National approximation. Coverage varies by MAC and state — confirm against the specific LCD/NCD and article that applies to your jurisdiction and date of service.
| ICD-10 | Description |
|---|---|
| A85.8 | Other specified viral encephalitis |
| B08.3 | Erythema infectiosum [fifth disease] |
| B20 | Human immunodeficiency virus [HIV] disease |
| B25.0 | Cytomegaloviral pneumonitis |
| B25.1 | Cytomegaloviral hepatitis |
| B25.2 | Cytomegaloviral pancreatitis |
| B25.8 | Other cytomegaloviral diseases |
| B25.9 | Cytomegaloviral disease, unspecified |
| C88.00 | Waldenstrom macroglobulinemia not having achieved remission |
| C90.00 | Multiple myeloma not having achieved remission |
| C90.02 | Multiple myeloma in relapse |
| C91.10 | Chronic lymphocytic leukemia of B-cell type not having achieved remission |
| C91.11 | Chronic lymphocytic leukemia of B-cell type in remission |
| C91.12 | Chronic lymphocytic leukemia of B-cell type in relapse |
| D47.3 | Essential (hemorrhagic) thrombocythemia |
| D55.0 | Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency |
| D55.1 | Anemia due to other disorders of glutathione metabolism |
| D55.21 | Anemia due to pyruvate kinase deficiency |
| D55.29 | Anemia due to other disorders of glycolytic enzymes |
| D55.3 | Anemia due to disorders of nucleotide metabolism |
| D55.8 | Other anemias due to enzyme disorders |
| D55.9 | Anemia due to enzyme disorder, unspecified |
| D56.0 | Alpha thalassemia |
| D56.1 | Beta thalassemia |
| D56.2 | Delta-beta thalassemia |
| D56.3 | Thalassemia minor |
| D56.4 | Hereditary persistence of fetal hemoglobin [HPFH] |
| D56.5 | Hemoglobin E-beta thalassemia |
| D56.8 | Other thalassemias |
| D56.9 | Thalassemia, unspecified |
| D57.00 | Hb-SS disease with crisis, unspecified |
| D57.01 | Hb-SS disease with acute chest syndrome |
| D57.02 | Hb-SS disease with splenic sequestration |
| D57.03 | Hb-SS disease with cerebral vascular involvement |
| D57.04 | Hb-SS disease with dactylitis |
| D57.09 | Hb-SS disease with crisis with other specified complication |
| D57.1 | Sickle-cell disease without crisis |
| D57.20 | Sickle-cell/Hb-C disease without crisis |
| D57.211 | Sickle-cell/Hb-C disease with acute chest syndrome |
| D57.212 | Sickle-cell/Hb-C disease with splenic sequestration |
| D57.213 | Sickle-cell/Hb-C disease with cerebral vascular involvement |
| D57.214 | Sickle-cell/Hb-C disease with dactylitis |
| D57.218 | Sickle-cell/Hb-C disease with crisis with other specified complication |
| D57.219 | Sickle-cell/Hb-C disease with crisis, unspecified |
| D57.3 | Sickle-cell trait |
| D57.414 | Sickle-cell thalassemia, unspecified, with dactylitis |
| D57.434 | Sickle-cell thalassemia beta zero with dactylitis |
| D57.454 | Sickle-cell thalassemia beta plus with dactylitis |
| D57.80 | Other sickle-cell disorders without crisis |
| D57.811 | Other sickle-cell disorders with acute chest syndrome |
| D57.812 | Other sickle-cell disorders with splenic sequestration |
| D57.813 | Other sickle-cell disorders with cerebral vascular involvement |
| D57.814 | Other sickle-cell disorders with dactylitis |
| D57.818 | Other sickle-cell disorders with crisis with other specified complication |
| D57.819 | Other sickle-cell disorders with crisis, unspecified |
| D58.0 | Hereditary spherocytosis |
| D58.1 | Hereditary elliptocytosis |
| D58.2 | Other hemoglobinopathies |
| D58.8 | Other specified hereditary hemolytic anemias |
| D58.9 | Hereditary hemolytic anemia, unspecified |
| D59.0 | Drug-induced autoimmune hemolytic anemia |
| D59.11 | Warm autoimmune hemolytic anemia |
| D59.12 | Cold autoimmune hemolytic anemia |
| D59.13 | Mixed type autoimmune hemolytic anemia |
| D59.9 | Acquired hemolytic anemia, unspecified |
| D61.01 | Constitutional (pure) red blood cell aplasia |
| D61.02 | Shwachman-Diamond syndrome |
| D61.810 | Antineoplastic chemotherapy induced pancytopenia |
| D61.811 | Other drug-induced pancytopenia |
| D61.818 | Other pancytopenia |
| D69.0 | Allergic purpura |
| D69.3 | Immune thrombocytopenic purpura |
| D69.41 | Evans syndrome |
| D69.42 | Congenital and hereditary thrombocytopenia purpura |
| D69.49 | Other primary thrombocytopenia |
| D80.0 | Hereditary hypogammaglobulinemia |
| D80.1 | Nonfamilial hypogammaglobulinemia |
| D80.2 | Selective deficiency of immunoglobulin A [IgA] |
| D80.3 | Selective deficiency of immunoglobulin G [IgG] subclasses |
| D80.4 | Selective deficiency of immunoglobulin M [IgM] |
| D80.5 | Immunodeficiency with increased immunoglobulin M [IgM] |
| D80.6 | Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia |
| D80.7 | Transient hypogammaglobulinemia of infancy |
| D80.8 | Other immunodeficiencies with predominantly antibody defects |
| D80.9 | Immunodeficiency with predominantly antibody defects, unspecified |
| D81.0 | Severe combined immunodeficiency [SCID] with reticular dysgenesis |
| D81.1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers |
| D81.2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers |
| D81.4 | Nezelof's syndrome |
| D81.5 | Purine nucleoside phosphorylase [PNP] deficiency |
| D81.6 | Major histocompatibility complex class I deficiency |
| D81.7 | Major histocompatibility complex class II deficiency |
| D81.82 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] |
| D81.89 | Other combined immunodeficiencies |
| D81.9 | Combined immunodeficiency, unspecified |
| D82.0 | Wiskott-Aldrich syndrome |
| D82.1 | Di George's syndrome |
| D82.2 | Immunodeficiency with short-limbed stature |
| D82.3 | Immunodeficiency following hereditary defective response to Epstein-Barr virus |
| D82.4 | Hyperimmunoglobulin E [IgE] syndrome |
| D82.8 | Immunodeficiency associated with other specified major defects |
| D82.9 | Immunodeficiency associated with major defect, unspecified |
| D83.0 | Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function |
| D83.1 | Common variable immunodeficiency with predominant immunoregulatory T-cell disorders |
| D83.2 | Common variable immunodeficiency with autoantibodies to B- or T-cells |
| D83.8 | Other common variable immunodeficiencies |
| D83.9 | Common variable immunodeficiency, unspecified |
| D84.0 | Lymphocyte function antigen-1 [LFA-1] defect |
| D84.1 | Defects in the complement system |
| D84.9 | Immunodeficiency, unspecified |
| D89.3 | Immune reconstitution syndrome |
| D89.810 | Acute graft-versus-host disease |
| D89.811 | Chronic graft-versus-host disease |
| D89.812 | Acute on chronic graft-versus-host disease |
| D89.813 | Graft-versus-host disease, unspecified |
| D89.82 | Autoimmune lymphoproliferative syndrome [ALPS] |
| D89.831 | Cytokine release syndrome, grade 1 |
| D89.832 | Cytokine release syndrome, grade 2 |
| D89.833 | Cytokine release syndrome, grade 3 |
| D89.834 | Cytokine release syndrome, grade 4 |
| D89.835 | Cytokine release syndrome, grade 5 |
| D89.839 | Cytokine release syndrome, grade unspecified |
| D89.84 | IgG4-related disease |
| D89.89 | Other specified disorders involving the immune mechanism, not elsewhere classified |
| D89.9 | Disorder involving the immune mechanism, unspecified |
| G04.81 | Other encephalitis and encephalomyelitis |
| G11.3 | Cerebellar ataxia with defective DNA repair |
| G13.0 | Paraneoplastic neuromyopathy and neuropathy |
| G13.1 | Other systemic atrophy primarily affecting central nervous system in neoplastic disease |
| G25.82 | Stiff-man syndrome |
| G35.A | Relapsing-remitting multiple sclerosis |
| G60.3 | Idiopathic progressive neuropathy |
| G61.0 | Guillain-Barre syndrome |
| G61.81 | Chronic inflammatory demyelinating polyneuritis |
| G61.82 | Multifocal motor neuropathy |
| G61.89 | Other inflammatory polyneuropathies |
| G62.81 | Critical illness polyneuropathy |
| G62.89 | Other specified polyneuropathies |
| G64 | Other disorders of peripheral nervous system |
| G70.00 | Myasthenia gravis without (acute) exacerbation |
| G70.01 | Myasthenia gravis with (acute) exacerbation |
| G70.80 | Lambert-Eaton syndrome, unspecified |
| G70.81 | Lambert-Eaton syndrome in disease classified elsewhere |
| G70.9 | Myoneural disorder, unspecified |
| G72.49 | Other inflammatory and immune myopathies, not elsewhere classified |
| G72.81 | Critical illness myopathy |
| G72.89 | Other specified myopathies |
| G73.1 | Lambert-Eaton syndrome in neoplastic disease |
| G73.3 | Myasthenic syndromes in other diseases classified elsewhere |
| H54.7 | Unspecified visual loss |
| L10.0 | Pemphigus vulgaris |
| L10.1 | Pemphigus vegetans |
| L10.2 | Pemphigus foliaceous |
| L10.3 | Brazilian pemphigus [fogo selvagem] |
| L10.4 | Pemphigus erythematosus |
| L10.5 | Drug-induced pemphigus |
| L10.81 | Paraneoplastic pemphigus |
| L10.89 | Other pemphigus |
| L10.9 | Pemphigus, unspecified |
| L12.0 | Bullous pemphigoid |
| L12.1 | Cicatricial pemphigoid |
| L12.8 | Other pemphigoid |
| L12.9 | Pemphigoid, unspecified |
| L13.8 | Other specified bullous disorders |
| L95.0 | Livedoid vasculitis |
| L95.9 | Vasculitis limited to the skin, unspecified |
| M30.3 | Mucocutaneous lymph node syndrome [Kawasaki] |
| M33.00 | Juvenile dermatomyositis, organ involvement unspecified |
| M33.01 | Juvenile dermatomyositis with respiratory involvement |
| M33.02 | Juvenile dermatomyositis with myopathy |
| M33.03 | Juvenile dermatomyositis without myopathy |
| M33.09 | Juvenile dermatomyositis with other organ involvement |
| M33.10 | Other dermatomyositis, organ involvement unspecified |
| M33.11 | Other dermatomyositis with respiratory involvement |
| M33.12 | Other dermatomyositis with myopathy |
| M33.13 | Other dermatomyositis without myopathy |
| M33.19 | Other dermatomyositis with other organ involvement |
| M33.20 | Polymyositis, organ involvement unspecified |
| M33.21 | Polymyositis with respiratory involvement |
| M33.22 | Polymyositis with myopathy |
| M33.29 | Polymyositis with other organ involvement |
| M33.90 | Dermatopolymyositis, unspecified, organ involvement unspecified |
| M33.91 | Dermatopolymyositis, unspecified with respiratory involvement |
| M33.92 | Dermatopolymyositis, unspecified with myopathy |
| M33.93 | Dermatopolymyositis, unspecified without myopathy |
| M33.99 | Dermatopolymyositis, unspecified with other organ involvement |
| M36.0 | Dermato(poly)myositis in neoplastic disease |
| M60.80 | Other myositis, unspecified site |
| R78.81 | Bacteremia |
| T86.10 | Unspecified complication of kidney transplant |
| T86.11 | Kidney transplant rejection |
| T86.12 | Kidney transplant failure |
| T86.13 | Kidney transplant infection |
| T86.19 | Other complication of kidney transplant |
| T86.21 | Heart transplant rejection |
| T86.22 | Heart transplant failure |
| T86.23 | Heart transplant infection |
| T86.298 | Other complications of heart transplant |
| T86.5 | Complications of stem cell transplant |
| Z41.8 | Encounter for other procedures for purposes other than remedying health state |
| Z48.21 | Encounter for aftercare following heart transplant |
| Z48.22 | Encounter for aftercare following kidney transplant |
| Z48.23 | Encounter for aftercare following liver transplant |
| Z48.24 | Encounter for aftercare following lung transplant |
| Z48.280 | Encounter for aftercare following heart-lung transplant |
| Z48.288 | Encounter for aftercare following multiple organ transplant |
| Z48.290 | Encounter for aftercare following bone marrow transplant |
| Z48.298 | Encounter for aftercare following other organ transplant |
| Z94.0 | Kidney transplant status |
| Z94.1 | Heart transplant status |
| Z94.81 | Bone marrow transplant status |
| Z94.84 | Stem cells transplant status |
Frequently asked questions
Which ICD-10 codes support medical necessity for CPT J2791?
Medicare coverage policies (LCDs/NCDs and Billing & Coding articles) list 212 ICD-10 diagnosis codes that support medical necessity for CPT J2791. The covered codes are listed on this page. Coverage varies by MAC/state — always confirm against the policy that applies to you.
What is a medical-necessity (LCD/NCD) crosswalk?
A claim whose procedure isn't supported by a covered diagnosis denies as "not medically necessary" (CARC 50). CMS coverage policies define which diagnoses justify a procedure; this page is the ICD-10 → CPT J2791 view of that relationship.
Catch medical-necessity denials before you bill. CareNiva scrubs claims against LCD/NCD coverage and flags unsupported diagnoses — in the same platform you run visits and billing.
More free billing tools: all crosswalks · NCCI edits · Medicare fees · denial codes
Informational only, not coding, billing, or legal advice. Based on CMS Medicare Coverage Database data; verify the current LCD/NCD for your MAC before billing.
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