ICD-10-CM category
D81: Combined immunodeficiencies
Codes under D81 (Combined immunodeficiencies). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| D81.0 | Severe combined immunodeficiency [SCID] with reticular dysgenesis | ✓ |
| D81.1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers | ✓ |
| D81.2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers | ✓ |
| D81.3 | Adenosine deaminase [ADA] deficiency | — |
| D81.4 | Nezelof's syndrome | ✓ |
| D81.5 | Purine nucleoside phosphorylase [PNP] deficiency | ✓ |
| D81.6 | Major histocompatibility complex class I deficiency | ✓ |
| D81.7 | Major histocompatibility complex class II deficiency | ✓ |
| D81.8 | Other combined immunodeficiencies | — |
| D81.9 | Combined immunodeficiency, unspecified | ✓ |
| D81.30 | Adenosine deaminase deficiency, unspecified | ✓ |
| D81.31 | Severe combined immunodeficiency due to adenosine deaminase deficiency | ✓ |
| D81.32 | Adenosine deaminase 2 deficiency | ✓ |
| D81.39 | Other adenosine deaminase deficiency | ✓ |
| D81.81 | Biotin-dependent carboxylase deficiency | — |
| D81.82 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] | ✓ |
| D81.89 | Other combined immunodeficiencies | ✓ |
| D81.810 | Biotinidase deficiency | ✓ |
| D81.818 | Other biotin-dependent carboxylase deficiency | ✓ |
| D81.819 | Biotin-dependent carboxylase deficiency, unspecified | ✓ |
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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
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