ICD-10-CM category
D57: Sickle-cell disorders
Codes under D57 (Sickle-cell disorders). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| D57.0 | Hb-SS disease with crisis | — |
| D57.0 | Hb-SS disease with crisis | — |
| D57.00 | Hb-SS disease with crisis, unspecified | ✓ |
| D57.00 | Hb-SS disease with crisis, unspecified | ✓ |
| D57.01 | Hb-SS disease with acute chest syndrome | ✓ |
| D57.01 | Hb-SS disease with acute chest syndrome | ✓ |
| D57.1 | Sickle-cell disease without crisis | ✓ |
| D57.1 | Sickle-cell disease without crisis | ✓ |
| D57.02 | Hb-SS disease with splenic sequestration | ✓ |
| D57.02 | Hb-SS disease with splenic sequestration | ✓ |
| D57.2 | Sickle-cell/Hb-C disease | — |
| D57.2 | Sickle-cell/Hb-C disease | — |
| D57.03 | Hb-SS disease with cerebral vascular involvement | ✓ |
| D57.03 | Hb-SS disease with cerebral vascular involvement | ✓ |
| D57.3 | Sickle-cell trait | ✓ |
| D57.3 | Sickle-cell trait | ✓ |
| D57.04 | Hb-SS disease with dactylitis | ✓ |
| D57.04 | Hb-SS disease with dactylitis | ✓ |
| D57.4 | Sickle-cell thalassemia | — |
| D57.4 | Sickle-cell thalassemia | — |
| D57.8 | Other sickle-cell disorders | — |
| D57.8 | Other sickle-cell disorders | — |
| D57.09 | Hb-SS disease with crisis with other specified complication | ✓ |
| D57.09 | Hb-SS disease with crisis with other specified complication | ✓ |
| D57.20 | Sickle-cell/Hb-C disease without crisis | ✓ |
| D57.20 | Sickle-cell/Hb-C disease without crisis | ✓ |
| D57.21 | Sickle-cell/Hb-C disease with crisis | — |
| D57.21 | Sickle-cell/Hb-C disease with crisis | — |
| D57.40 | Sickle-cell thalassemia without crisis | ✓ |
| D57.40 | Sickle-cell thalassemia without crisis | ✓ |
| D57.41 | Sickle-cell thalassemia, unspecified, with crisis | — |
| D57.41 | Sickle-cell thalassemia, unspecified, with crisis | — |
| D57.42 | Sickle-cell thalassemia beta zero without crisis | ✓ |
| D57.42 | Sickle-cell thalassemia beta zero without crisis | ✓ |
| D57.43 | Sickle-cell thalassemia beta zero with crisis | — |
| D57.43 | Sickle-cell thalassemia beta zero with crisis | — |
| D57.44 | Sickle-cell thalassemia beta plus without crisis | ✓ |
| D57.44 | Sickle-cell thalassemia beta plus without crisis | ✓ |
| D57.45 | Sickle-cell thalassemia beta plus with crisis | — |
| D57.45 | Sickle-cell thalassemia beta plus with crisis | — |
| D57.80 | Other sickle-cell disorders without crisis | ✓ |
| D57.80 | Other sickle-cell disorders without crisis | ✓ |
| D57.81 | Other sickle-cell disorders with crisis | — |
| D57.81 | Other sickle-cell disorders with crisis | — |
| D57.211 | Sickle-cell/Hb-C disease with acute chest syndrome | ✓ |
| D57.211 | Sickle-cell/Hb-C disease with acute chest syndrome | ✓ |
| D57.212 | Sickle-cell/Hb-C disease with splenic sequestration | ✓ |
| D57.212 | Sickle-cell/Hb-C disease with splenic sequestration | ✓ |
| D57.213 | Sickle-cell/Hb-C disease with cerebral vascular involvement | ✓ |
| D57.213 | Sickle-cell/Hb-C disease with cerebral vascular involvement | ✓ |
| D57.214 | Sickle-cell/Hb-C disease with dactylitis | ✓ |
| D57.214 | Sickle-cell/Hb-C disease with dactylitis | ✓ |
| D57.218 | Sickle-cell/Hb-C disease with crisis with other specified complication | ✓ |
| D57.218 | Sickle-cell/Hb-C disease with crisis with other specified complication | ✓ |
| D57.219 | Sickle-cell/Hb-C disease with crisis, unspecified | ✓ |
| D57.219 | Sickle-cell/Hb-C disease with crisis, unspecified | ✓ |
| D57.411 | Sickle-cell thalassemia, unspecified, with acute chest syndrome | ✓ |
| D57.411 | Sickle-cell thalassemia, unspecified, with acute chest syndrome | ✓ |
| D57.412 | Sickle-cell thalassemia, unspecified, with splenic sequestration | ✓ |
| D57.412 | Sickle-cell thalassemia, unspecified, with splenic sequestration | ✓ |
| D57.413 | Sickle-cell thalassemia, unspecified, with cerebral vascular involvement | ✓ |
| D57.413 | Sickle-cell thalassemia, unspecified, with cerebral vascular involvement | ✓ |
| D57.414 | Sickle-cell thalassemia, unspecified, with dactylitis | ✓ |
| D57.414 | Sickle-cell thalassemia, unspecified, with dactylitis | ✓ |
| D57.418 | Sickle-cell thalassemia, unspecified, with crisis with other specified complication | ✓ |
| D57.418 | Sickle-cell thalassemia, unspecified, with crisis with other specified complication | ✓ |
| D57.419 | Sickle-cell thalassemia, unspecified, with crisis | ✓ |
| D57.419 | Sickle-cell thalassemia, unspecified, with crisis | ✓ |
| D57.431 | Sickle-cell thalassemia beta zero with acute chest syndrome | ✓ |
| D57.431 | Sickle-cell thalassemia beta zero with acute chest syndrome | ✓ |
| D57.432 | Sickle-cell thalassemia beta zero with splenic sequestration | ✓ |
| D57.432 | Sickle-cell thalassemia beta zero with splenic sequestration | ✓ |
| D57.433 | Sickle-cell thalassemia beta zero with cerebral vascular involvement | ✓ |
| D57.433 | Sickle-cell thalassemia beta zero with cerebral vascular involvement | ✓ |
| D57.434 | Sickle-cell thalassemia beta zero with dactylitis | ✓ |
| D57.434 | Sickle-cell thalassemia beta zero with dactylitis | ✓ |
| D57.438 | Sickle-cell thalassemia beta zero with crisis with other specified complication | ✓ |
| D57.438 | Sickle-cell thalassemia beta zero with crisis with other specified complication | ✓ |
| D57.439 | Sickle-cell thalassemia beta zero with crisis, unspecified | ✓ |
| D57.439 | Sickle-cell thalassemia beta zero with crisis, unspecified | ✓ |
| D57.451 | Sickle-cell thalassemia beta plus with acute chest syndrome | ✓ |
| D57.451 | Sickle-cell thalassemia beta plus with acute chest syndrome | ✓ |
| D57.452 | Sickle-cell thalassemia beta plus with splenic sequestration | ✓ |
| D57.452 | Sickle-cell thalassemia beta plus with splenic sequestration | ✓ |
| D57.453 | Sickle-cell thalassemia beta plus with cerebral vascular involvement | ✓ |
| D57.453 | Sickle-cell thalassemia beta plus with cerebral vascular involvement | ✓ |
| D57.454 | Sickle-cell thalassemia beta plus with dactylitis | ✓ |
| D57.454 | Sickle-cell thalassemia beta plus with dactylitis | ✓ |
| D57.458 | Sickle-cell thalassemia beta plus with crisis with other specified complication | ✓ |
| D57.458 | Sickle-cell thalassemia beta plus with crisis with other specified complication | ✓ |
| D57.459 | Sickle-cell thalassemia beta plus with crisis, unspecified | ✓ |
| D57.459 | Sickle-cell thalassemia beta plus with crisis, unspecified | ✓ |
| D57.811 | Other sickle-cell disorders with acute chest syndrome | ✓ |
| D57.811 | Other sickle-cell disorders with acute chest syndrome | ✓ |
| D57.812 | Other sickle-cell disorders with splenic sequestration | ✓ |
| D57.812 | Other sickle-cell disorders with splenic sequestration | ✓ |
| D57.813 | Other sickle-cell disorders with cerebral vascular involvement | ✓ |
| D57.813 | Other sickle-cell disorders with cerebral vascular involvement | ✓ |
| D57.814 | Other sickle-cell disorders with dactylitis | ✓ |
| D57.814 | Other sickle-cell disorders with dactylitis | ✓ |
| D57.818 | Other sickle-cell disorders with crisis with other specified complication | ✓ |
| D57.818 | Other sickle-cell disorders with crisis with other specified complication | ✓ |
| D57.819 | Other sickle-cell disorders with crisis, unspecified | ✓ |
| D57.819 | Other sickle-cell disorders with crisis, unspecified | ✓ |
Frequently asked questions
What is ICD-10-CM code D57?
D57 is an ICD-10-CM category covering Sickle-cell disorders. It contains 104 more specific diagnosis codes, 86 of which are billable.
Is D57 a billable code?
No — D57 is a category header and isn't billable on its own. Code to the highest level of specificity using one of its subcodes (for example D57.0 — Hb-SS disease with crisis). 86 of the 104 codes under D57 are billable.
What codes fall under D57?
D57 includes D57.0, D57.0, D57.00, D57.00, D57.01, plus 99 more. See the full list with descriptions and billable status above.
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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
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