D89: Other disorders involving the immune mechanism, not elsewhere classified
Codes under D89 (Other disorders involving the immune mechanism, not elsewhere classified). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| D89.0 | Polyclonal hypergammaglobulinemia | ✓ |
| D89.0 | Polyclonal hypergammaglobulinemia | ✓ |
| D89.1 | Cryoglobulinemia | ✓ |
| D89.1 | Cryoglobulinemia | ✓ |
| D89.2 | Hypergammaglobulinemia, unspecified | ✓ |
| D89.2 | Hypergammaglobulinemia, unspecified | ✓ |
| D89.3 | Immune reconstitution syndrome | ✓ |
| D89.3 | Immune reconstitution syndrome | ✓ |
| D89.4 | Mast cell activation syndrome and related disorders | — |
| D89.4 | Mast cell activation syndrome and related disorders | — |
| D89.8 | Other specified disorders involving the immune mechanism, not elsewhere classified | — |
| D89.8 | Other specified disorders involving the immune mechanism, not elsewhere classified | — |
| D89.9 | Disorder involving the immune mechanism, unspecified | ✓ |
| D89.9 | Disorder involving the immune mechanism, unspecified | ✓ |
| D89.40 | Mast cell activation, unspecified | ✓ |
| D89.40 | Mast cell activation, unspecified | ✓ |
| D89.41 | Monoclonal mast cell activation syndrome | ✓ |
| D89.41 | Monoclonal mast cell activation syndrome | ✓ |
| D89.42 | Idiopathic mast cell activation syndrome | ✓ |
| D89.42 | Idiopathic mast cell activation syndrome | ✓ |
| D89.43 | Secondary mast cell activation | ✓ |
| D89.43 | Secondary mast cell activation | ✓ |
| D89.44 | Hereditary alpha tryptasemia | ✓ |
| D89.44 | Hereditary alpha tryptasemia | ✓ |
| D89.49 | Other mast cell activation disorder | ✓ |
| D89.49 | Other mast cell activation disorder | ✓ |
| D89.81 | Graft-versus-host disease | — |
| D89.81 | Graft-versus-host disease | — |
| D89.82 | Autoimmune lymphoproliferative syndrome [ALPS] | ✓ |
| D89.82 | Autoimmune lymphoproliferative syndrome [ALPS] | ✓ |
| D89.83 | Cytokine release syndrome | — |
| D89.83 | Cytokine release syndrome | — |
| D89.84 | IgG4-related disease | ✓ |
| D89.84 | IgG4-related disease | ✓ |
| D89.89 | Other specified disorders involving the immune mechanism, not elsewhere classified | ✓ |
| D89.89 | Other specified disorders involving the immune mechanism, not elsewhere classified | ✓ |
| D89.810 | Acute graft-versus-host disease | ✓ |
| D89.810 | Acute graft-versus-host disease | ✓ |
| D89.811 | Chronic graft-versus-host disease | ✓ |
| D89.811 | Chronic graft-versus-host disease | ✓ |
| D89.812 | Acute on chronic graft-versus-host disease | ✓ |
| D89.812 | Acute on chronic graft-versus-host disease | ✓ |
| D89.813 | Graft-versus-host disease, unspecified | ✓ |
| D89.813 | Graft-versus-host disease, unspecified | ✓ |
| D89.831 | Cytokine release syndrome, grade 1 | ✓ |
| D89.831 | Cytokine release syndrome, grade 1 | ✓ |
| D89.832 | Cytokine release syndrome, grade 2 | ✓ |
| D89.832 | Cytokine release syndrome, grade 2 | ✓ |
| D89.833 | Cytokine release syndrome, grade 3 | ✓ |
| D89.833 | Cytokine release syndrome, grade 3 | ✓ |
| D89.834 | Cytokine release syndrome, grade 4 | ✓ |
| D89.834 | Cytokine release syndrome, grade 4 | ✓ |
| D89.835 | Cytokine release syndrome, grade 5 | ✓ |
| D89.835 | Cytokine release syndrome, grade 5 | ✓ |
| D89.839 | Cytokine release syndrome, grade unspecified | ✓ |
| D89.839 | Cytokine release syndrome, grade unspecified | ✓ |
Frequently asked questions
What is ICD-10-CM code D89?
D89 is an ICD-10-CM category covering Other disorders involving the immune mechanism, not elsewhere classified. It contains 56 more specific diagnosis codes, 48 of which are billable.
Is D89 a billable code?
No — D89 is a category header and isn't billable on its own. Code to the highest level of specificity using one of its subcodes (for example D89.0 — Polyclonal hypergammaglobulinemia). 48 of the 56 codes under D89 are billable.
What codes fall under D89?
D89 includes D89.0, D89.0, D89.1, D89.1, D89.2, plus 51 more. See the full list with descriptions and billable status above.
More free billing tools: all ICD-10 categories · ICD-10 search · denial codes · Medicare fees
Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
Code the diagnosis right
Join providers across the country delivering modern virtual care with CareNiva. Free to start, ready in minutes.
100% Satisfaction Guaranteed — try it risk-free