R65: Symptoms and signs specifically associated with systemic inflammation and infection

Codes under R65 (Symptoms and signs specifically associated with systemic inflammation and infection). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.

Code	Description	Billable
R65.1	Systemic inflammatory response syndrome (SIRS) of non-infectious origin	—
R65.2	Severe sepsis	—
R65.10	Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction	✓
R65.11	Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction	✓
R65.20	Severe sepsis without septic shock	✓
R65.21	Severe sepsis with septic shock	✓

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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.

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