R65: Symptoms and signs specifically associated with systemic inflammation and infection
Codes under R65 (Symptoms and signs specifically associated with systemic inflammation and infection). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| R65.1 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin | — |
| R65.1 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin | — |
| R65.2 | Severe sepsis | — |
| R65.2 | Severe sepsis | — |
| R65.10 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction | ✓ |
| R65.10 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction | ✓ |
| R65.11 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction | ✓ |
| R65.11 | Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction | ✓ |
| R65.20 | Severe sepsis without septic shock | ✓ |
| R65.20 | Severe sepsis without septic shock | ✓ |
| R65.21 | Severe sepsis with septic shock | ✓ |
| R65.21 | Severe sepsis with septic shock | ✓ |
Frequently asked questions
What is ICD-10-CM code R65?
R65 is an ICD-10-CM category covering Symptoms and signs specifically associated with systemic inflammation and infection. It contains 12 more specific diagnosis codes, 8 of which are billable.
Is R65 a billable code?
No — R65 is a category header and isn't billable on its own. Code to the highest level of specificity using one of its subcodes (for example R65.1 — Systemic inflammatory response syndrome (SIRS) of non-infectious origin). 8 of the 12 codes under R65 are billable.
What codes fall under R65?
R65 includes R65.1, R65.1, R65.2, R65.2, R65.10, plus 7 more. See the full list with descriptions and billable status above.
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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
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