Z16: Resistance to antimicrobial drugs
Codes under Z16 (Resistance to antimicrobial drugs). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| Z16.1 | Resistance to beta lactam antibiotics | — |
| Z16.1 | Resistance to beta lactam antibiotics | — |
| Z16.2 | Resistance to other antibiotics | — |
| Z16.2 | Resistance to other antibiotics | — |
| Z16.3 | Resistance to other antimicrobial drugs | — |
| Z16.3 | Resistance to other antimicrobial drugs | — |
| Z16.10 | Resistance to unspecified beta lactam antibiotics | ✓ |
| Z16.10 | Resistance to unspecified beta lactam antibiotics | ✓ |
| Z16.11 | Resistance to penicillins | ✓ |
| Z16.11 | Resistance to penicillins | ✓ |
| Z16.12 | Extended spectrum beta lactamase (ESBL) resistance | ✓ |
| Z16.12 | Extended spectrum beta lactamase (ESBL) resistance | ✓ |
| Z16.13 | Resistance to carbapenem | ✓ |
| Z16.13 | Resistance to carbapenem | ✓ |
| Z16.19 | Resistance to other specified beta lactam antibiotics | ✓ |
| Z16.19 | Resistance to other specified beta lactam antibiotics | ✓ |
| Z16.20 | Resistance to unspecified antibiotic | ✓ |
| Z16.20 | Resistance to unspecified antibiotic | ✓ |
| Z16.21 | Resistance to vancomycin | ✓ |
| Z16.21 | Resistance to vancomycin | ✓ |
| Z16.22 | Resistance to vancomycin related antibiotics | ✓ |
| Z16.22 | Resistance to vancomycin related antibiotics | ✓ |
| Z16.23 | Resistance to quinolones and fluoroquinolones | ✓ |
| Z16.23 | Resistance to quinolones and fluoroquinolones | ✓ |
| Z16.24 | Resistance to multiple antibiotics | ✓ |
| Z16.24 | Resistance to multiple antibiotics | ✓ |
| Z16.29 | Resistance to other single specified antibiotic | ✓ |
| Z16.29 | Resistance to other single specified antibiotic | ✓ |
| Z16.30 | Resistance to unspecified antimicrobial drugs | ✓ |
| Z16.30 | Resistance to unspecified antimicrobial drugs | ✓ |
| Z16.31 | Resistance to antiparasitic drug(s) | ✓ |
| Z16.31 | Resistance to antiparasitic drug(s) | ✓ |
| Z16.32 | Resistance to antifungal drug(s) | ✓ |
| Z16.32 | Resistance to antifungal drug(s) | ✓ |
| Z16.33 | Resistance to antiviral drug(s) | ✓ |
| Z16.33 | Resistance to antiviral drug(s) | ✓ |
| Z16.34 | Resistance to antimycobacterial drug(s) | — |
| Z16.34 | Resistance to antimycobacterial drug(s) | — |
| Z16.35 | Resistance to multiple antimicrobial drugs | ✓ |
| Z16.35 | Resistance to multiple antimicrobial drugs | ✓ |
| Z16.39 | Resistance to other specified antimicrobial drug | ✓ |
| Z16.39 | Resistance to other specified antimicrobial drug | ✓ |
| Z16.341 | Resistance to single antimycobacterial drug | ✓ |
| Z16.341 | Resistance to single antimycobacterial drug | ✓ |
| Z16.342 | Resistance to multiple antimycobacterial drugs | ✓ |
| Z16.342 | Resistance to multiple antimycobacterial drugs | ✓ |
Frequently asked questions
What is ICD-10-CM code Z16?
Z16 is an ICD-10-CM category covering Resistance to antimicrobial drugs. It contains 46 more specific diagnosis codes, 38 of which are billable.
Is Z16 a billable code?
No — Z16 is a category header and isn't billable on its own. Code to the highest level of specificity using one of its subcodes (for example Z16.1 — Resistance to beta lactam antibiotics). 38 of the 46 codes under Z16 are billable.
What codes fall under Z16?
Z16 includes Z16.1, Z16.1, Z16.2, Z16.2, Z16.3, plus 41 more. See the full list with descriptions and billable status above.
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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
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