CPT 95921: ICD-10 codes that support medical necessity
These ICD-10-CM diagnoses support medical necessity for CPT 95921 under Medicare coverage policies (LCDs, NCDs, and Billing & Coding articles). Billing CPT 95921 with a diagnosis that isn't covered typically denies as CARC 50 — not medically necessary.
National approximation. Coverage varies by MAC and state — confirm against the specific LCD/NCD and article that applies to your jurisdiction and date of service.
| ICD-10 | Description |
|---|---|
| E08.21 | Diabetes mellitus due to underlying condition with diabetic nephropathy |
| E08.40 | Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified |
| E08.41 | Diabetes mellitus due to underlying condition with diabetic mononeuropathy |
| E08.42 | Diabetes mellitus due to underlying condition with diabetic polyneuropathy |
| E08.43 | Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy |
| E08.51 | Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy without gangrene |
| E09.42 | Drug or chemical induced diabetes mellitus with neurological complications with diabetic polyneuropathy |
| E10.40 | Type 1 diabetes mellitus with diabetic neuropathy, unspecified |
| E10.41 | Type 1 diabetes mellitus with diabetic mononeuropathy |
| E10.42 | Type 1 diabetes mellitus with diabetic polyneuropathy |
| E10.43 | Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy |
| E10.44 | Type 1 diabetes mellitus with diabetic amyotrophy |
| E10.49 | Type 1 diabetes mellitus with other diabetic neurological complication |
| E10.610 | Type 1 diabetes mellitus with diabetic neuropathic arthropathy |
| E11.40 | Type 2 diabetes mellitus with diabetic neuropathy, unspecified |
| E11.41 | Type 2 diabetes mellitus with diabetic mononeuropathy |
| E11.42 | Type 2 diabetes mellitus with diabetic polyneuropathy |
| E11.43 | Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy |
| E11.44 | Type 2 diabetes mellitus with diabetic amyotrophy |
| E11.49 | Type 2 diabetes mellitus with other diabetic neurological complication |
| E11.610 | Type 2 diabetes mellitus with diabetic neuropathic arthropathy |
| E11.65 | Type 2 diabetes mellitus with hyperglycemia |
| E13.40 | Other specified diabetes mellitus with diabetic neuropathy, unspecified |
| E13.41 | Other specified diabetes mellitus with diabetic mononeuropathy |
| E13.42 | Other specified diabetes mellitus with diabetic polyneuropathy |
| E13.43 | Other specified diabetes mellitus with diabetic autonomic (poly)neuropathy |
| E13.44 | Other specified diabetes mellitus with diabetic amyotrophy |
| E13.49 | Other specified diabetes mellitus with other diabetic neurological complication |
| E13.610 | Other specified diabetes mellitus with diabetic neuropathic arthropathy |
| E85.0 | Non-neuropathic heredofamilial amyloidosis |
| E85.1 | Neuropathic heredofamilial amyloidosis |
| E85.3 | Secondary systemic amyloidosis |
| E85.4 | Organ-limited amyloidosis |
| E85.81 | Light chain (AL) amyloidosis |
| E85.82 | Wild-type transthyretin-related (ATTR) amyloidosis |
| E85.89 | Other amyloidosis |
| G12.23 | Primary lateral sclerosis |
| G12.24 | Familial motor neuron disease |
| G12.25 | Progressive spinal muscle atrophy |
| G20.A1 | Parkinson's disease without dyskinesia, without mention of fluctuations |
| G20.A2 | Parkinson's disease without dyskinesia, with fluctuations |
| G20.B1 | Parkinson's disease with dyskinesia, without mention of fluctuations |
| G20.B2 | Parkinson's disease with dyskinesia, with fluctuations |
| G20.C | Parkinsonism, unspecified |
| G23.0 | Hallervorden-Spatz disease |
| G23.1 | Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski] |
| G23.2 | Striatonigral degeneration |
| G23.8 | Other specified degenerative diseases of basal ganglia |
| G31.83 | Neurocognitive disorder with Lewy bodies |
| G56.83 | Other specified mononeuropathies of bilateral upper limbs |
| G57.83 | Other specified mononeuropathies of bilateral lower limbs |
| G60.3 | Idiopathic progressive neuropathy |
| G60.8 | Other hereditary and idiopathic neuropathies |
| G60.9 | Hereditary and idiopathic neuropathy, unspecified |
| G61.82 | Multifocal motor neuropathy |
| G62.9 | Polyneuropathy, unspecified |
| G90.09 | Other idiopathic peripheral autonomic neuropathy |
| G90.3 | Multi-system degeneration of the autonomic nervous system |
| G90.50 | Complex regional pain syndrome I, unspecified |
| G90.511 | Complex regional pain syndrome I of right upper limb |
| G90.512 | Complex regional pain syndrome I of left upper limb |
| G90.513 | Complex regional pain syndrome I of upper limb, bilateral |
| G90.519 | Complex regional pain syndrome I of unspecified upper limb |
| G90.521 | Complex regional pain syndrome I of right lower limb |
| G90.522 | Complex regional pain syndrome I of left lower limb |
| G90.523 | Complex regional pain syndrome I of lower limb, bilateral |
| G90.529 | Complex regional pain syndrome I of unspecified lower limb |
| G90.59 | Complex regional pain syndrome I of other specified site |
| G90.A | Postural orthostatic tachycardia syndrome [POTS] |
| G99.0 | Autonomic neuropathy in diseases classified elsewhere |
| I95.1 | Orthostatic hypotension |
| L74.4 | Anhidrosis |
| R00.0 | Tachycardia, unspecified |
| R55 | Syncope and collapse |
| R61 | Generalized hyperhidrosis |
Frequently asked questions
Which ICD-10 codes support medical necessity for CPT 95921?
Medicare coverage policies (LCDs/NCDs and Billing & Coding articles) list 75 ICD-10 diagnosis codes that support medical necessity for CPT 95921. The covered codes are listed on this page. Coverage varies by MAC/state — always confirm against the policy that applies to you.
What is a medical-necessity (LCD/NCD) crosswalk?
A claim whose procedure isn't supported by a covered diagnosis denies as "not medically necessary" (CARC 50). CMS coverage policies define which diagnoses justify a procedure; this page is the ICD-10 → CPT 95921 view of that relationship.
More free billing tools: all crosswalks · NCCI edits · Medicare fees · denial codes
Informational only, not coding, billing, or legal advice. Based on CMS Medicare Coverage Database data; verify the current LCD/NCD for your MAC before billing.
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