R53: Malaise and fatigue
Codes under R53 (Malaise and fatigue). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| R53.0 | Neoplastic (malignant) related fatigue | ✓ |
| R53.0 | Neoplastic (malignant) related fatigue | ✓ |
| R53.1 | Weakness | ✓ |
| R53.1 | Weakness | ✓ |
| R53.2 | Functional quadriplegia | ✓ |
| R53.2 | Functional quadriplegia | ✓ |
| R53.8 | Other malaise and fatigue | — |
| R53.8 | Other malaise and fatigue | — |
| R53.81 | Other malaise | ✓ |
| R53.81 | Other malaise | ✓ |
| R53.82 | Chronic fatigue, unspecified | ✓ |
| R53.82 | Chronic fatigue, unspecified | ✓ |
| R53.83 | Other fatigue | ✓ |
| R53.83 | Other fatigue | ✓ |
Frequently asked questions
What is ICD-10-CM code R53?
R53 is an ICD-10-CM category covering Malaise and fatigue. It contains 14 more specific diagnosis codes, 12 of which are billable.
Is R53 a billable code?
No — R53 is a category header and isn't billable on its own. Code to the highest level of specificity using one of its subcodes (for example R53.0 — Neoplastic (malignant) related fatigue). 12 of the 14 codes under R53 are billable.
What codes fall under R53?
R53 includes R53.0, R53.0, R53.1, R53.1, R53.2, plus 9 more. See the full list with descriptions and billable status above.
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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
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