E88: Other and unspecified metabolic disorders
Codes under E88 (Other and unspecified metabolic disorders). A ✓ marks a billable (fully specified) code; category codes without a ✓ are not billable on their own.
| Code | Description | Billable |
|---|---|---|
| E88.0 | Disorders of plasma-protein metabolism, not elsewhere classified | — |
| E88.0 | Disorders of plasma-protein metabolism, not elsewhere classified | — |
| E88.01 | Alpha-1-antitrypsin deficiency | ✓ |
| E88.01 | Alpha-1-antitrypsin deficiency | ✓ |
| E88.1 | Lipodystrophy, not elsewhere classified | — |
| E88.1 | Lipodystrophy, not elsewhere classified | — |
| E88.02 | Plasminogen deficiency | ✓ |
| E88.02 | Plasminogen deficiency | ✓ |
| E88.2 | Lipomatosis, not elsewhere classified | ✓ |
| E88.2 | Lipomatosis, not elsewhere classified | ✓ |
| E88.3 | Tumor lysis syndrome | ✓ |
| E88.3 | Tumor lysis syndrome | ✓ |
| E88.4 | Mitochondrial metabolism disorders | — |
| E88.4 | Mitochondrial metabolism disorders | — |
| E88.8 | Other specified metabolic disorders | — |
| E88.8 | Other specified metabolic disorders | — |
| E88.09 | Other disorders of plasma-protein metabolism, not elsewhere classified | ✓ |
| E88.09 | Other disorders of plasma-protein metabolism, not elsewhere classified | ✓ |
| E88.9 | Metabolic disorder, unspecified | ✓ |
| E88.9 | Metabolic disorder, unspecified | ✓ |
| E88.10 | Lipodystrophy, unspecified | ✓ |
| E88.10 | Lipodystrophy, unspecified | ✓ |
| E88.11 | Partial lipodystrophy | ✓ |
| E88.11 | Partial lipodystrophy | ✓ |
| E88.12 | Generalized lipodystrophy | ✓ |
| E88.12 | Generalized lipodystrophy | ✓ |
| E88.13 | Localized lipodystrophy | ✓ |
| E88.13 | Localized lipodystrophy | ✓ |
| E88.14 | HIV-associated lipodystrophy | ✓ |
| E88.14 | HIV-associated lipodystrophy | ✓ |
| E88.19 | Other lipodystrophy, not elsewhere classified | ✓ |
| E88.19 | Other lipodystrophy, not elsewhere classified | ✓ |
| E88.40 | Mitochondrial metabolism disorder, unspecified | ✓ |
| E88.40 | Mitochondrial metabolism disorder, unspecified | ✓ |
| E88.41 | MELAS syndrome | ✓ |
| E88.41 | MELAS syndrome | ✓ |
| E88.42 | MERRF syndrome | ✓ |
| E88.42 | MERRF syndrome | ✓ |
| E88.43 | Disorders of mitochondrial tRNA synthetases | ✓ |
| E88.43 | Disorders of mitochondrial tRNA synthetases | ✓ |
| E88.49 | Other mitochondrial metabolism disorders | ✓ |
| E88.49 | Other mitochondrial metabolism disorders | ✓ |
| E88.81 | Metabolic syndrome and other insulin resistance | — |
| E88.81 | Metabolic syndrome and other insulin resistance | — |
| E88.82 | Obesity due to disruption of MC4R pathway | ✓ |
| E88.82 | Obesity due to disruption of MC4R pathway | ✓ |
| E88.89 | Other specified metabolic disorders | ✓ |
| E88.89 | Other specified metabolic disorders | ✓ |
| E88.810 | Metabolic syndrome | ✓ |
| E88.810 | Metabolic syndrome | ✓ |
| E88.811 | Insulin resistance syndrome, Type A | ✓ |
| E88.811 | Insulin resistance syndrome, Type A | ✓ |
| E88.818 | Other insulin resistance | ✓ |
| E88.818 | Other insulin resistance | ✓ |
| E88.819 | Insulin resistance, unspecified | ✓ |
| E88.819 | Insulin resistance, unspecified | ✓ |
| E88.A | Wasting disease (syndrome) due to underlying condition | ✓ |
| E88.A | Wasting disease (syndrome) due to underlying condition | ✓ |
Frequently asked questions
What is ICD-10-CM code E88?
E88 is an ICD-10-CM category covering Other and unspecified metabolic disorders. It contains 58 more specific diagnosis codes, 48 of which are billable.
Is E88 a billable code?
No — E88 is a category header and isn't billable on its own. Code to the highest level of specificity using one of its subcodes (for example E88.0 — Disorders of plasma-protein metabolism, not elsewhere classified). 48 of the 58 codes under E88 are billable.
What codes fall under E88?
E88 includes E88.0, E88.0, E88.01, E88.01, E88.1, plus 53 more. See the full list with descriptions and billable status above.
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Informational only, not coding or medical advice. Verify against the official ICD-10-CM (FY2026) and your payer's guidelines.
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